Next Treatments: New and upcoming atopic dermatitis treatments

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Approved

Approved for atopic dermatitis in the United States.

Adqueydifamilast

How it’s taken: Topical What stands outBlocks PDE4 to lower inflammation in the body Stage reached: ApprovedUS trial sites: yes Latest update: Feb 12, 2026FDA approval for eczema

Nemluvionemolizumab How it’s taken: Injection What stands outInjection every 4 weeksBlocks IL-31 receptor, part of the docking point for IL-31, a signal involved in skin immunity Stage reached: ApprovedUS trial sites: yes Latest update: Updated recently. Jul 13, 2026Phase 2 study started

How it’s taken: Topical What stands outActivates AhR, a sensor inside cells that responds to chemical signals and changes gene activity Stage reached: ApprovedUS trial sites: yes Latest update: Dec 29, 2025Phase 3 study started

Phase 3

Phase 3 is the last trial stage before a company can ask for approval.

tilrekimig How it’s taken: Injection What stands outNew approach in eczemaActs on both IL-4 and TSLP, which no approved eczema treatment currently does; also targets IL-13 (like Adbry and Ebglyss)Binds to IL-13 (a signal molecule that plays a role in allergic inflammation), IL-4 (a signal that helps control antibody production and immune responses) and TSLP (a signal that helps activate and attract immune cells) Stage reached: Phase 3US trial sites: yes Latest update: Updated recently. Aug 17, 2026Phase 3 study started

rezpegaldesleukin How it’s taken: Injection What stands outNew approach in eczemaA made form of IL-2, a signal that grows T cells, including the regulatory ones that calm immunityInjection every 2, 4 or 12 weeks in trials Stage reached: Phase 3US trial sites: yes Latest update: Updated recently. Aug 7, 2026Phase 3 study started

SHR-1819 How it’s taken: Injection What stands outInjection every week or 2 weeks in trials Stage reached: Phase 3US trial sites: no Latest update: Updated recently. Aug 26, 2026Phase 3 study completed

611 How it’s taken: Injection What stands outSame target as DupixentBinds to IL-4 receptor, the docking point for both the IL-4 and IL-13 signalsInjection every week, 2, 3 or 4 weeks in trials Stage reached: Phase 3US trial sites: no Latest update: Updated recently. Aug 18, 2026Phase 3 study completed

LNK01001 How it’s taken: Pill What stands out Stage reached: Phase 3US trial sites: no Latest update: Jan 12, 2026Phase 3 study completed

stapokibart How it’s taken: Injection What stands outSame target as DupixentBinds to IL-4 receptor, the docking point for both the IL-4 and IL-13 signalsInjection every 2 or 3 weeks in trials Stage reached: Phase 3US trial sites: no Latest update: Nov 26, 2025Phase 2 study completed

MH004 How it’s taken: Topical What stands out Stage reached: Phase 3US trial sites: no Latest update: Aug 15, 2025Phase 3 study completed

GX-03 How it’s taken: Topical What stands out Stage reached: Phase 3US trial sites: yes Latest update: Jul 11, 2025Phase 2/3 study started

TQH2722 How it’s taken: Injection What stands outSame target as DupixentBinds to IL-4 receptor, the docking point for both the IL-4 and IL-13 signalsInjection every 2 weeks in trials Stage reached: Phase 3US trial sites: no Latest update: Sep 11, 2025Phase 3 main data collected

VC005 How it’s taken: Topical What stands out Stage reached: Phase 3US trial sites: no Latest update: Jun 1, 2026Phase 2 study started

LW402 How it’s taken: Pill What stands out Stage reached: Phase 3US trial sites: no Latest update: Mar 3, 2026Phase 3 study started

QY201 How it’s taken: Pill What stands out Stage reached: Phase 3US trial sites: unknown Latest update: Dec 19, 2025Phase 2 study completed

QLM3003 How it’s taken: Topical What stands out Stage reached: Phase 3US trial sites: no Latest update: May 16, 2025Phase 3 study started

PG-011 How it’s taken: Topical What stands out Stage reached: Phase 3US trial sites: no Latest update: Nov 19, 2024Phase 3 main data collected

ICP-332 How it’s taken: Pill What stands out Stage reached: Phase 3US trial sites: no Latest update: Nov 14, 2024Phase 3 study started

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Phase 2 and earlier

Treatments in Phase 2 or earlier, including academic research no company has picked up.

zumilokibart How it’s taken: Injection What stands outInjection every 12 or 24 weeks in trialsSame target as Adbry and Ebglyss, but dosed less oftenBinds to IL-13, a signal molecule that plays a role in allergic inflammation Stage reached: Phase 2US trial sites: yes Latest update: May 14, 2025Phase 2 study started

barzolvolimab How it’s taken: Injection What stands outInjection every 4 weeks in trialsNew approach in eczemaBinds to KIT (c-Kit), a growth switch involved in mast-cell development and function Stage reached: Phase 2US trial sites: yes Latest update: May 6, 2026Phase 2 main data collected

afimkibart How it’s taken: Injection What stands outNew approach in eczemaBinds to TL1A, a signal that boosts T-cell activation Stage reached: Phase 2US trial sites: yes Latest update: Updated recently. Jul 22, 2026Phase 2 main data collected

rilzabrutinib How it’s taken: Pill What stands outNew approach in eczemaBlocks BTK, an enzyme immune cells rely on to work Stage reached: Phase 2US trial sites: yes Latest update: Updated recently. Jul 13, 2026Phase 2 results posted

camoteskimab How it’s taken: Injection What stands outNew approach in eczemaBinds to IL-18, an inflammation signal that rallies immune cells Stage reached: Phase 2US trial sites: yes Latest update: May 28, 2026Phase 2 study started

lunsekimig How it’s taken: Injection What stands outNew approach in eczemaActs on TSLP, which no approved eczema treatment currently does; also targets IL-13 (like Adbry and Ebglyss)Binds to IL-13 (a signal molecule that plays a role in allergic inflammation) and TSLP (a signal that helps activate and attract immune cells) Stage reached: Phase 2US trial sites: yes Latest update: Apr 9, 2026Phase 2 study completed

temtokibart How it’s taken: Injection What stands outNew approach in eczemaBinds to IL-22 receptor, part of the docking point for the IL-22 signalInjection every 2 weeks in trials Stage reached: Phase 2US trial sites: yes Latest update: Feb 12, 2026Phase 2 results posted

galvokimig How it’s taken: Injection What stands outNew approach in eczemaActs on both IL-17A and IL-17F, which no approved eczema treatment currently does; also targets IL-13 (like Adbry and Ebglyss)Binds to IL-17A (an immune signal involved in defense against microbes and tissue protection), IL-17F (an immune signal involved in defense against microbes and tissue protection) and IL-13 (a signal molecule that plays a role in allergic inflammation) Stage reached: Phase 2US trial sites: yes Latest update: Dec 29, 2025Phase 2 study started

KT-621 How it’s taken: Pill What stands outNew approach in eczemaBreaks down STAT6, a relay inside cells that carries immune signals to genes Stage reached: Phase 2US trial sites: yes Latest update: Nov 24, 2025Phase 2 study started

bosakitug How it’s taken: Injection What stands outNew approach in eczemaBinds to TSLP, a signal that helps activate and attract immune cellsInjection every week or 2 weeks in trials Stage reached: Phase 2US trial sites: yes Latest update: Oct 15, 2025Phase 2 results posted

lutikizumab How it’s taken: Injection What stands outNew approach in eczemaBinds to IL-1 alpha (an alarm signal released from damaged cells that helps start inflammation) and IL-1 beta (an inflammation signal that activates immune cells)Injection every 2 weeks in trials Stage reached: Phase 2US trial sites: yes Latest update: Dec 19, 2024Phase 2 study started

soquelitinib How it’s taken: Pill What stands outNew approach in eczemaBlocks ITK, a relay inside T cells that helps control their activation Stage reached: Phase 2US trial sites: yes Latest update: Feb 24, 2026Phase 1 study completed

donzakimig How it’s taken: Injection What stands outNew approach in eczemaActs on IL-22, which no approved eczema treatment currently does; also targets IL-13 (like Adbry and Ebglyss)Binds to IL-22 (a signal that helps barrier cells repair and respond to inflammation) and IL-13 (a signal molecule that plays a role in allergic inflammation) Stage reached: Phase 2US trial sites: yes Latest update: Sep 19, 2025Phase 1/2 study completed · Basic-science trial

OpSCF How it’s taken: Injection What stands outMonoclonal antibodyInjection every 2 or 4 weeks in trials Stage reached: Phase 2US trial sites: yes Latest update: Updated recently. Sep 11, 2026Phase 2 results posted

ENV-294 How it’s taken: Pill What stands out Stage reached: Phase 2US trial sites: yes Latest update: Updated recently. Jun 29, 2026Phase 2 study started

HY209 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: yes Latest update: Apr 13, 2026Phase 2 study completed

JNJ-95597528 How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: yes Latest update: Jan 20, 2026Phase 2 study started

vibozilimod How it’s taken: Pill What stands outImmunomodulator Stage reached: Phase 2US trial sites: yes Latest update: Dec 30, 2025Phase 2 results posted

YR001 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: yes Latest update: Nov 20, 2025Phase 2 study completed

GIA632 How it’s taken: Not recorded What stands out Stage reached: Phase 2US trial sites: yes Latest update: Nov 10, 2025Phase 2 study started

CGB-500 with tofacitinib How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: yes Latest update: Oct 30, 2025Phase 2 study completed

AK120 How it’s taken: Injection What stands outInjection every week, 2 or 3 weeks in trials Stage reached: Phase 2US trial sites: yes Latest update: Sep 11, 2025Phase 2 study completed

EVO756 How it’s taken: Pill What stands out Stage reached: Phase 2US trial sites: yes Latest update: Aug 26, 2025Phase 2 study started

TRIV-509 How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: yes Latest update: Aug 26, 2025Phase 2 study started

EP262 How it’s taken: Pill What stands out Stage reached: Phase 2US trial sites: yes Latest update: Aug 24, 2025Phase 2 results posted

BFB759 How it’s taken: Not recorded What stands outHuman mAb Stage reached: Phase 2US trial sites: yes Latest update: Jul 15, 2025Phase 2 study started

ATI-045 How it’s taken: Not recorded What stands out Stage reached: Phase 2US trial sites: yes Latest update: May 30, 2025Phase 2 study started

TDM-180935 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: yes Latest update: Apr 8, 2025Phase 2 study completed

modzatinib How it’s taken: Pill What stands outKinase inhibitor Stage reached: Phase 2US trial sites: yes Latest update: Mar 31, 2025Phase 2 study completed

orismilast How it’s taken: Pill What stands outBlocks PDE4 to lower inflammation in the body Stage reached: Phase 2US trial sites: yes Latest update: Mar 7, 2025Phase 2 results posted

EVO101 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: yes Latest update: Mar 5, 2025Phase 2 results posted

zabedosertib How it’s taken: Pill What stands outSerine/threonine kinase inhibitor Stage reached: Phase 2US trial sites: yes Latest update: Feb 18, 2025Phase 2 results posted

ASN008 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: yes Latest update: Dec 27, 2024Phase 2 results posted

B244 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: yes Latest update: Dec 19, 2024Phase 2 results posted

idrebormilast How it’s taken: Topical What stands outBlocks PDE4 to lower inflammation in the body Stage reached: Phase 2US trial sites: yes Latest update: Oct 2, 2024Phase 2 results posted

ATTO-3712 How it’s taken: Injection What stands out Stage reached: Phase 1US trial sites: yes Latest update: Updated recently. Aug 13, 2026Phase 1 study completed

IMG-007 How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: yes Latest update: Jun 5, 2026Phase 2 study started

PF-08049820 How it’s taken: Pill What stands out Stage reached: Phase 2US trial sites: yes Latest update: Dec 15, 2025Phase 1 study completed · Basic-science trial

LT-002-158 How it’s taken: Pill What stands outNew approach in eczemaBreaks down IRAK4, a relay inside cells for innate alarm signals Stage reached: Phase 2US trial sites: no Latest update: Nov 25, 2025Phase 1 study completed · Eczema target not confirmed

STMC-103H How it’s taken: Not recorded What stands out Stage reached: Phase 2US trial sites: yes Latest update: Oct 21, 2025Phase 1/2 study completed · Prevention trial

GHZ339 How it’s taken: Not recorded What stands out Stage reached: Phase 2US trial sites: yes Latest update: May 16, 2025Phase 2 study started

AMTX-100 CF How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: yes Latest update: May 2, 2025Phase 1/2 results posted

IN-115314 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: no Latest update: Updated recently. Jul 13, 2026Phase 2 main data collected

ATTO-1310 How it’s taken: Injection What stands out Stage reached: Phase 1US trial sites: yes Latest update: Jun 11, 2026Phase 1 study completed

comekibart How it’s taken: Injection What stands outSame target as DupixentBinds to IL-4 receptor, the docking point for both the IL-4 and IL-13 signalsInjection every 2, 4 or 8 weeks in trials Stage reached: Phase 2US trial sites: unknown Latest update: Apr 29, 2026Phase 2 study completed

RSS0393 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: no Latest update: Apr 10, 2026Phase 2 study completed

EVO301 How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: no Latest update: Nov 17, 2025Phase 2 study completed

LNK01004 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: no Latest update: Jul 24, 2025Phase 2 study completed

MK-6194 How it’s taken: Injection What stands outInjection every 2 weeks in trials Stage reached: Phase 1US trial sites: yes Latest update: Jun 5, 2025Phase 1 results posted

HSK44459 How it’s taken: Pill What stands out Stage reached: Phase 2US trial sites: no Latest update: May 22, 2025Phase 2 study started

ADSTEM Inj How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: unknown Latest update: Jan 26, 2023Phase 2 main data collected

APG777 + APG990 How it’s taken: Injection What stands out Stage reached: Phase 1US trial sites: no Latest update: Updated recently. Aug 29, 2026Phase 1 main data collected

BYN-001 How it’s taken: Injection What stands outNew approach in eczemaBinds to IL-25, a signal that promotes type 2 immune responses Stage reached: No phase reachedUS trial sites: unknown Latest update: Aug 5, 2026Phase 1 study posted

SM17 How it’s taken: Injection What stands outMonoclonal antibodyInjection every 2 weeks in trials Stage reached: Phase 2US trial sites: no Latest update: Mar 31, 2026Phase 2 study started

ARQ-234 How it’s taken: Injection What stands out Stage reached: Phase 1US trial sites: yes Latest update: Mar 2, 2026Phase 1 study started

IBI3002 How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: no Latest update: Feb 6, 2026Phase 2 study started

ZL-82 How it’s taken: Pill What stands out Stage reached: Phase 2US trial sites: no Latest update: Feb 3, 2026Phase 2 study started

IBI356 How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: no Latest update: Dec 31, 2025Phase 2 study started

SHR-1905 How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: no Latest update: Nov 7, 2025Phase 2 study started

CM512 How it’s taken: Injection What stands out Stage reached: Phase 2US trial sites: no Latest update: Sep 12, 2025Phase 1 study completed

BBT001 How it’s taken: Not recorded What stands out Stage reached: Phase 1US trial sites: yes Latest update: Aug 9, 2025Phase 1 study started

LPX-TI641 How it’s taken: Pill What stands out Stage reached: Phase 1US trial sites: yes Latest update: Jun 15, 2025Phase 1 study started

TRB-061 How it’s taken: Injection What stands outInjection every 4 weeks in trials Stage reached: Phase 1US trial sites: no Latest update: May 2, 2025Phase 1 study started

zabalafin How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: no Latest update: Mar 25, 2025Phase 2 study started

SYX-5219 How it’s taken: Pill What stands out Stage reached: Phase 1US trial sites: yes Latest update: Feb 26, 2025Phase 1 study started

GM-XANTHO onitment How it’s taken: Not recorded What stands out Stage reached: Phase 2US trial sites: no Latest update: Feb 24, 2025Phase 1/2 study completed · Purpose listed as other

PF-07832837 How it’s taken: Not recorded What stands out Stage reached: Phase 1US trial sites: yes Latest update: Nov 5, 2024Phase 1 study started

QX4533 How it’s taken: Pill What stands out Stage reached: Phase 1US trial sites: no Latest update: Updated recently. Sep 14, 2026Phase 1 study started

BGB-45035 How it’s taken: Pill What stands out Stage reached: Phase 1US trial sites: no Latest update: Jun 2, 2026Phase 1 study completed · Eczema target not confirmed

HL-300 How it’s taken: Topical What stands out Stage reached: Phase 2US trial sites: no Latest update: May 26, 2026Phase 1/2 study started

BMS-986326 How it’s taken: Not recorded What stands out Stage reached: Phase 1US trial sites: no Latest update: Nov 6, 2025Phase 1 study completed

XKH001 How it’s taken: Injection What stands outInjection every 4 weeks in trials Stage reached: No phase reachedUS trial sites: no Latest update: Jul 8, 2025Phase 2 study posted

GB-7624 How it’s taken: Injection What stands out Stage reached: Phase 1US trial sites: no Latest update: Mar 27, 2025Phase 1 study started

TLL-018 How it’s taken: Pill What stands out Stage reached: Phase 1US trial sites: no Latest update: Aug 28, 2023Phase 1 study completed

DCY636 How it’s taken: Not recorded What stands out Stage reached: Phase 1US trial sites: no Latest update: Jun 2, 2026Phase 1 study started

REGN20423 How it’s taken: Not recorded What stands out Stage reached: Phase 1US trial sites: no Latest update: May 22, 2026Phase 1 study started

SSGJ-716 How it’s taken: Injection What stands out Stage reached: Phase 1US trial sites: no Latest update: May 18, 2026Phase 1 study started

SKB575 How it’s taken: Injection What stands out Stage reached: Phase 1US trial sites: no Latest update: Mar 31, 2026Phase 1 study started

S-4321 How it’s taken: Injection What stands out Stage reached: Phase 1US trial sites: no Latest update: Mar 6, 2026Phase 1 study posted · Eczema target not confirmed

ZL-1503 How it’s taken: Not recorded What stands out Stage reached: Phase 1US trial sites: no Latest update: Dec 1, 2025Phase 1 study started

QLS12010 How it’s taken: Pill What stands out Stage reached: Phase 1US trial sites: unknown Latest update: Mar 31, 2025Phase 1 study started

CU-10101 How it’s taken: Topical What stands out Stage reached: Phase 1US trial sites: no Latest update: Sep 12, 2024Phase 1 study started

HXN5003 How it’s taken: Injection What stands out Stage reached: No phase reachedUS trial sites: no Latest update: Sep 3, 2026Phase 1 study posted

HXN6005 How it’s taken: Injection What stands out Stage reached: No phase reachedUS trial sites: no Latest update: Aug 24, 2026Phase 1/2 study posted

TRIV-573 How it’s taken: Injection What stands out Stage reached: No phase reachedUS trial sites: unknown Latest update: Aug 24, 2026Phase 2 study posted

HRS-8797 How it’s taken: Pill What stands out Stage reached: No phase reachedUS trial sites: no Latest update: Jul 13, 2026Phase 1 study posted

IBI3033 How it’s taken: Injection What stands out Stage reached: No phase reachedUS trial sites: no Latest update: Apr 24, 2026Phase 1 study posted

AK139 How it’s taken: Injection What stands out Stage reached: No phase reachedUS trial sites: unknown Latest update: Mar 30, 2026Phase 2 study posted

CMS-D001 How it’s taken: Not recorded What stands out Stage reached: No phase reachedUS trial sites: no Latest update: Mar 11, 2026Phase 2 study posted

SIM0278 How it’s taken: Injection What stands out Stage reached: No phase reachedUS trial sites: no Latest update: Sep 16, 2025Phase 2 study posted

S. hominis A 9 ProductNational Institute of Allergy and Infectious Diseases (NIAID) How it’s taken: Topical What stands out Stage reached: Phase 1 · ResearchersUS trial sites: yes Latest update: May 22, 2025Phase 1 study started

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No longer pursued

A trial was stopped early and no other trial of this treatment is running or planned, as ClinicalTrials.gov records it, or the sponsor announced the programme's end. The reason shown is the sponsor's own.

amlitelimabNot better than existing options · Sanofi · Jul 24, 2026 How it’s taken: Injection What stands outInjection every 4 weeks in trialsNew approach in eczemaBinds to OX40L, the signal that flips the OX40 switch on T cells Stage reached: Stopped · Phase 3US trial sites: yes Latest update: Jun 10, 2026Phase 3 main data collected

rocatinlimabSafety (a rare cancer) · Amgen/Kyowa Kirin · Mar 3, 2026 How it’s taken: Injection What stands outInjection every 4 or 8 weeks in trialsNew approach in eczemaBinds to OX40, a switch on T cells that keeps an immune response going Stage reached: Stopped · Phase 3US trial sites: yes Latest update: Updated recently. Aug 28, 2026Phase 3 results posted

tipasertidegCompany decision · Sanofi · Nov 20, 2025 How it’s taken: Pill What stands outProtein degrader Stage reached: Stopped · Phase 2US trial sites: yes Latest update: Nov 20, 2025Phase 2 study stopped early

aletekitugDidn't work well enough · GlaxoSmithKline · Jul 29, 2025 How it’s taken: Injection What stands outMonoclonal antibody Stage reached: Stopped · Phase 2US trial sites: yes Latest update: Jun 16, 2026Phase 2 results posted · Trial stopped early

ucenprubartDidn't work well enough · Eli Lilly and Company · Mar 14, 2025 How it’s taken: Injection What stands outNew approach in eczemaBinds to CD200 receptor, a receptor that helps limit inflammatory signalsInjection every 2 or 4 weeks in trials Stage reached: Stopped · Phase 2US trial sites: yes Latest update: Dec 2, 2025Phase 2 results posted · Trial stopped early

zelnecirnonSafety (severe liver injury) · RAPT Therapeutics · Nov 11, 2024 How it’s taken: Pill What stands outNew approach in eczemaBlocks CCR4, a homing receptor that helps guide immune cells Stage reached: Stopped · Phase 2US trial sites: yes Latest update: Feb 25, 2026Phase 2 results posted · Trial stopped early

benralizumabDidn't work well enough · AstraZeneca · Sep 13, 2022 How it’s taken: Injection What stands outNew approach in eczemaBinds to IL-5 receptor, part of the docking point for IL-5, a signal that helps immune cells called eosinophils surviveInjection every 4 weeks in trials Stage reached: Stopped · Phase 2US trial sites: yes Latest update: Aug 22, 2025Phase 2 results posted

baricitinibRegulatory issue · Eli Lilly and Company · Jun 13, 2022 How it’s taken: Pill What stands outBlocks JAK enzymes, decreasing the activity of the immune system Stage reached: Stopped · Phase 3US trial sites: yes Latest update: May 22, 2026Phase 3 study completed

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